京都大学大学院農学研究科 食品生物科学専攻食品生理機能学分野 大日向研究室 京都大学
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2017/04/04 updated
2017
L-Ornithine and L-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1.
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K. Mol Nutr Food Res. 2017 Jul 18

Lacto-ghrestatin, a novel bovine milk-derived peptide, suppresses ghrelin secretion.
Aoki H, Nakato J, Mizushige T, Iwakura H, Sato M, Suzuki H, Kanamoto R, Ohinata K. FEBS Lett. 2017 Jul;591(14):2121-2130.

l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system.
Ho YY, Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, Ohinata K. Food Funct. 2017 Jun 1;8(6):2110-2114.

Rational identification of a novel soy-derived anxiolytic-like undecapeptide acting via gut-brain axis after oral administration.
Ami Ota, Akane Yamamoto, Saeko Kimura, Yukiha Mori, Takafumi Mizushige, Yoshiki Nagashima, Masaru Sato, Hideyuki Suzuki, Saori Odagiri, Daisuke Yamada, Masayuki Sekiguchi, Keiji Wada, Ryuhei Kanamoto, Kousaku Ohinata
Neurochemistry International. Volume 105 May 2017 Pages 51-57

2016

Soy-ghretropin, a novel ghrelin-releasing peptide derived from soy protein
Junya Nakato, Hayato Aoki, Hiroshi Iwakura, Hideyuki Suzuki, Ryuhei Kanamoto, Kousaku Ohinata
FEBS Letters.16 August 2016 Pages 2681-2689

2015

Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.
Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
Peptides. 2016 Mar 25. (16)30049-3.Epub 2016 Mar 14

A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice.
Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K.
Food Funct. 2015 Aug;6(8):2749-57.Epub 2015 Jul 8.

Antidepressant-like effect of food-derived pyroglutamyl peptides in mice.
Yamamoto Y, Mizushige T, Mori Y, Shimmura Y, Fukutomi R, Kanamoto R, Ohinata K.
Neuropeptides. 2015 Jun;51:25-9. Epub 2015 Apr 22.

2014

Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food intake in aged mice with ghrelin resistance.
Miyazaki Y, Kaneko K, Iguchi S, Mizushige T, Kanamoto R, Yoshikawa M, Shimizu T, Ohinata K.
Mol Nutr Food Res. 2014 Oct;58(10):2046-52.Epub 2014 Jul 22.

δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice.
Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K.
Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.Epub 2014 Jan 8.

Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities.
Kontani N, Omae R, Kagebayashi T, Kaneko K, Yamada Y, Mizushige T, Kanamoto R, Ohinata K.
Mol Nutr Food Res. 2014 Feb;58(2):359-64.Epub 2013 Sep 17.

Identification of novel β-lactoglobulin-derived peptides, wheylin-1 and -2, having anxiolytic-like activity in mice.
Yamada A, Mizushige T, Kanamoto R, Ohinata K.
Mol Nutr Food Res. 2014 Feb;58(2):353-8. Epub 2013 Sep 3.

2013

Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.
Mizushige T, Sawashi Y, Yamada A, Kanamoto R, Ohinata K.
FASEB J. 2013 Apr 11.

Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice.
Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K.
Neurosci Lett. 2013 Apr 6.

2012

Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide.
Kaneko K, Yoshikawa M, Ohinata K.
Neuropeptides. 2012 Dec;46(6):353-7. doi: 10.1016/j.npep.2012.10.003. Epub 2012 Nov 9.

Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.
Kagebayashi T, Kontani N, Yamada Y, Mizushige T, Arai T, Kino K, Ohinata K.
Mol Nutr Food Res. 2012 Sep;56(9):1456-63. doi: 10.1002/mnfr.201200168. Epub 2012 Aug 1.

Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice.
Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K.
Mol Nutr Food Res. 2012 Aug;56(8):1315-23. doi: 10.1002/mnfr.201200155. Epub 2012 Jun 20.

Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity.
Oda A, Kaneko K, Mizushige T, Lazarus M, Urade Y, Ohinata K.
J Neurochem. 2012 May 4

Complement C5a exhibits anxiolytic-like activity via the prostaglandin D2-DP1 receptor system coupled to adenosine A2A and GABAA receptors.
Miyamoto C, Yoshida M, Yoshikawa M, Mizushige T, Ohinata K.
Prostaglandins Other Lipid Mediat. 2012 May;98(1-2):17-22.

2011

Soymorphin-5, a soy-derived μ opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KK-Ay mice.
Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K.
Am J Physiol Endocrinol Metab. 2011 Nov 29.

β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS(2) receptor via activation of dopamine D(1) receptor in mice.
Hou IC, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K.
J Neurochem. 2011 Nov;119(4):785-90. doi: 10.1111/j.1471-4159.2011.07472.x. Epub 2011 Oct 10.

Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors.
Suzuki C, Miyamoto C, Furuyashiki T, Narumiya S, Ohinata K.
FEBS Lett. 2011 Jul 21;585(14):2357-62. Epub 2011 Jun 17.

Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice.
Yamada Y, Ohinata K, Lipkowski AW, Yoshikawa M.
Peptides. 2011 Feb;32(2):281-5. Epub 2010 Dec 1.

2010

Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems.
Kaneko K, Iwasaki M, Yoshikawa M, Ohinata K.
Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G799-805. Epub 2010 Jul 8.

Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.
Yamada Y, Iwasaki M, Usui H, Ohinata K, Marczak ED, Lipkowski AW, Yoshikawa M.
Peptides. 2010 May;31(5):909-14. Epub 2010 Feb 25.

Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice.
Kanegawa N, Suzuki C, Ohinata K.
FEBS Lett. 2010 Feb 5;584(3):599-604. Epub 2009 Dec 23.

2009

beta-Lactotensin derived from bovine beta-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice..

Hou IC, Yoshikawa M, Ohinata K.
Peptides. 2009 Dec;30(12):2228-32. Epub 2009 Aug 29.

Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice.
Ohinata K, Takagi K, Biyajima K, Kaneko K, Miyamoto C, Asakawa A, Eguchi N, Urade Y, Inui A, Yoshikawa M.
Prostaglandins Other Lipid Mediat. 2009 Dec;90(3-4):81-4. Epub 2009 Oct 1.

Orally administered novokinin, an angiotensin AT(2) receptor agonist, suppresses food intake via prostaglandin E(2)-dependent mechanism in mice.
Ohinata K, Fujiwata Y, Shingo F, Masaru I, Masatsugu H, Yoshikawa M.
Peptides
. 2009 Jun;30(6):1105-8. Epub 2009 Mar 24.

Orally administered zinc increases food intake via vagal stimulation in rats.
Ohinata K, Takemoto M, Kawanago M, Fushimi S, Shirakawa H, Goto T, Asakawa A, Komai M.
J Nutr. 2009 Mar;139(3):611-6. Epub 2009 Jan 21.

Angiotensin AT(2) receptor agonists act as anti-opioids via EP(3) receptor in mice.
Yamada Y, Ohinata K, Lipkowski AW, Yoshikawa M.
Peptides. 2009 Apr;30(4):735-9. Epub 2008 Nov 25.

2008

Accumulation of the bioactive peptides, novokinin, LPYPR and rubiscolin, in seeds of genetically modified soybean.
Nishizawa K, Kita A, Doi C, Yamada Y, Ohinata K, Yoshikawa M, Ishimoto M.
Biosci Biotechnol Biochem. 2008 Dec;72(12):3301-5. Epub 2008 Dec 7.

Food intake regulation by central complement system.
Ohinata K, Yoshikawa M.
Adv Exp Med Biol. 2008;632:35-46. Review.

Central prostaglandin D(2) exhibits anxiolytic-like activity via the DP(1) receptor in mice.
Zhao H, Ohinata K, Yoshikawa M.
Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):68-72. Epub 2008 Oct 21.

Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism.
Takenaka Y, Shimano T, Mori T, Hou IC, Ohinata K, Yoshikawa M.
Peptides. 2008 Dec;29(12):2175-8. Epub 2008 Sep 9.

Central prostaglandins in food intake regulation.
Ohinata K, Yoshikawa M.
Nutrition. 2008 Sep;24(9):798-801. Epub 2008 Jul 26. Review.

[Effect of biotin ingestion on the improvement of hypertension in SHRSP]
Komai M, Watanabe-Kamiyama M, Kamiyama S, Ohinata K, Horiuchi K, Furukawa Y, Shirakawa H.
Nippon Yakurigaku Zasshi. 2008 Apr;131(4):248-51.

Enterostatin (APGPR) suppresses the analgesic activity of morphine by a CCK-dependent mechanism.
Takenaka Y, Shimano T, Yamada Y, Yoshida M, Ohinata K, Yoshikawa M.
Peptides. 2008 Apr;29(4):559-63. Epub 2008 Jan 19.

Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice.
Ohinata K, Fujiwara Y, Fukumoto S, Iwai M, Horiuchi M, Yoshikawa M.
FEBS Lett. 2008 Mar 5;582(5):773-7. Epub 2008 Feb 5.

Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice.
Ohinata K, Takagi K, Biyajima K, Fujiwara Y, Fukumoto S, Eguchi N, Urade Y, Asakawa A, Fujimiya M, Inui A, Yoshikawa M.
FEBS Lett. 2008 Mar 5;582(5):679-84. Epub 2008 Feb 5.

Rubimetide (Met-Arg-Trp) derived from Rubisco exhibits anxiolytic-like activity via the DP1 receptor in male ddY mice.
Zhao H, Ohinata K, Yoshikawa M.
Peptides. 2008 Apr;29(4):629-32. Epub 2007 Dec 23.

Anti-hypertensive activity of genetically modified soybean seeds accumulating novokinin.
Yamada Y, Nishizawa K, Yokoo M, Zhao H, Onishi K, Teraishi M, Utsumi S, Ishimoto M, Yoshikawa M.
Peptides. 2008 Mar;29(3):331-7. Epub 2007 Dec 3.

Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT(2) receptor and prostaglandin IP receptor.
Yamada Y, Yamauchi D, Usui H, Zhao H, Yokoo M, Ohinata K, Iwai M, Horiuchi M, Yoshikawa M.
Peptides. 2008 Mar;29(3):412-8. Epub 2007 Dec 4.

Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats.
Zhao H, Usui H, Ohinata K, Yoshikawa M.
Peptides. 2008 Mar;29(3):345-9. Epub 2007 Nov 22.

Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats.
Watanabe-Kamiyama M, Kamiyama S, Horiuchi K, Ohinata K, Shirakawa H, Furukawa Y, Komai M.
Br J Nutr. 2008 Apr;99(4):756-63. Epub 2008 Jan 8.

A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs.
Yamada Y, Yamauchi D, Yokoo M, Ohinata K, Usui H, Yoshikawa M.
Biosci Biotechnol Biochem. 2008 Jan;72(1):257-9. Epub 2008 Jan 7.

2007

Soymorphins, novel mu opioid peptides derived from soy beta-conglycinin beta-subunit, have anxiolytic activities.
Ohinata K, Agui S, Yoshikawa M.
Biosci Biotechnol Biochem. 2007 Oct;71(10):2618-21. Epub 2007 Oct 7.

Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma1 and dopamine D1 receptors.
Hirata H, Sonoda S, Agui S, Yoshida M, Ohinata K, Yoshikawa M.
Peptides. 2007 Oct;28(10):1998-2003. Epub 2007 Jul 27.

beta-Lactotensin, a neurotensin agonist peptide derived from bovine beta-lactoglobulin, enhances memory consolidation in mice.
Ohinata K, Sonoda S, Inoue N, Yamauchi R, Wada K, Yoshikawa M.
Peptides
. 2007 Jul;28(7):1470-4. Epub 2007 Jun 8.

Suppression of food intake by a complement C3a agonist [Trp5]-oryzatensin(5-9).
Ohinata K, Suetsugu K, Fujiwara Y, Yoshikawa M.
Peptides
. 2007 Mar;28(3):602-6. Epub 2007 Jan 4.

Enterostatin (APGPR) enhances memory consolidation in mice.
Ohinata K, Sonoda S, Shimano T, Yoshikawa M.
Peptides. 2007 Mar;28(3):719-21. Epub 2006 Dec 18.

2006

Activation of prostaglandin E receptor EP4 subtype suppresses food intake in mice.
Ohinata K, Suetsugu K, Fujiwara Y, Yoshikawa M.
Prostaglandins Other Lipid Mediat. 2006 Oct;81(1-2):31-6. Epub 2006 Aug 4.

Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats.
Shirakawa H, Ohsaki Y, Minegishi Y, Takumi N, Ohinata K, Furukawa Y, Mizutani T, Komai M.
Biochim Biophys Acta. 2006 Oct;1760(10):1482-8. Epub 2006 Jun 6.

Arg-Ile-Tyr (RIY) derived from rapeseed protein decreases food intake and gastric emptying after oral administration in mice.
Marczak ED, Ohinata K, Lipkowski AW, Yoshikawa M.
Peptides. 2006 Sep;27(9):2065-8. Epub 2006 May 2.

[Trp3, Arg5]-ghrelin(1-5) stimulates growth hormone secretion and food intake via growth hormone secretagogue (GHS) receptor.
Ohinata K, Kobayashi K, Yoshikawa M.
Peptides. 2006 Jul;27(7):1632-7. Epub 2006 Mar 13.

Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats.
Ardiansyah, Shirakawa H, Koseki T, Ohinata K, Hashizume K, Komai M.
J Agric Food Chem. 2006 Mar 8;54(5):1914-20. Erratum in: J Agric Food Chem. 2006 Nov 29;54(24):9277.

2005以前

The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice.
Ohinata K, Shimano T, Yamauchi R, Sakurada S, Yanai K, Yoshikawa M.
Peptides. 2004 Dec;25(12):2135-8.

Design of a genetically modified soybean protein preventing hypertension based on an anti-hypertensive peptide derived from ovalbumin.
Matoba N, Yamada Y, Yoshikawa M.
Curr Med Chem Cardiovasc Hematol Agents. 2003 Jun;1(2):197-202.

Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor.
Yamauchi R, Ohinata K, Yoshikawa M.
Peptides. 2003 Dec;24(12):1955-61.

Optimal designing of beta-conglycinin to genetically incorporate RPLKPW, a potent anti-hypertensive peptide.
Onishi K, Matoba N, Yamada Y, Doyama N, Maruyama N, Utsumi S, Yoshikawa M.
Peptides. 2004 Jan;25(1):37-43.

EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor.
Asakawa A, Akio I, Ohinata K, Fujimiya M, Meguid MM, Yoshikawa M.
J Gastroenterol Hepatol. 2003 Jul;18(7):881-2.

Design of a highly potent anti-hypertensive peptide based on ovokinin(2-7).
Yamada Y, Matoba N, Usui H, Onishi K, Yoshikawa M.
Biosci Biotechnol Biochem
. 2002 Jun;66(6):1213-7.

Albutensin A and complement C3a decrease food intake in mice.
Ohinata K, Inui A, Asakawa A, Wada K, Wada E, Yoshikawa M.
Peptides
. 2002 Jan;23(1):127-33.

京都大学 京都大学 農学研究科 食品生物科学専攻
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京都大学大学院農学研究科食品生物科学専攻
食品生理機能学分野
〒611-0011 京都府宇治市五ヶ庄
Tel : 0774-38-3733